The combined effect of commercial tilapia collagen peptides and antioxidants against UV-induced skin photoaging in mice

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Food &

Function

Linking the chemistry and physics of food with health and nutrition

rsc.li/food-function

Volume 14

Number 13

7 July 2023

Pages 5823-6276

ISSN 2042-650X

PAPER

Dasong Liu et al.

The combined e ect of commercial tilapia collagen peptides

and antioxidants against UV-induced skin photoaging in

mice

Food &

Function

PAPER

Cite this: Food Funct., 2023, 14,

5936

Received 16th April 2023,

Accepted 30th May 2023

DOI: 10.1039/d3fo01516e

rsc.li/food-function

The combined eﬀect of commercial tilapia

collagen peptides and antioxidants against

UV-induced skin photoaging in mice†

Bo Song,

Dasong Liu,*

Tristan C. Liu,

b,c

Kexin Li,

b,c

Sai Wang,

b,c

Jianguo Liu,

b,c

Joe M. Regenstein,

Yuxuan Wu

and Peng Zhou

Chronic over-exposure to UV radiation leads to the damage of skin tissue. The aim of this study was to

investigate the eﬀects of collagen peptide (CP) and antioxidant (astaxanthin, vitamin C (Vc), and vitamin E

(Ve)) combinations on skin photoaging. Forty male UV-induced BALB/c mice were randomized and fed

saline or CP and antioxidants for 7 weeks using gavage feeding. The results showed that oral adminis-

tration of CP, CP combined with Vc and Ve (VCE) or Haematococcus pluvialis extract (HPE) signiﬁcantly (P

< 0.05) reduced a* of mouse skin and increased the content of Hyp and type I collagen to varying

degrees, thereby improving skin integrity. Furthermore, the combination of CP, HPE, and VCE showed

increased upregulation of antioxidant enzyme expression, reduced serum ROS, and decreased inhibition

of metalloproteinase expression compared to the other treatment groups. Thus, this combination showed

better eﬀects in inhibiting collagen degradation and maintaining the redox balance. The Nrf2/ARE and

TGF-β/Smad transcription systems are likely involved in these eﬀects. Therefore, the results suggest that a

diet containing CP, astaxanthin, and vitamins might be recommended to improve skin health and

appearance.

1. Introduction

Skin aging is one of the phenotypes of an organism’s aging

and is influenced by a combination of intrinsic and extrinsic

factors.

Intrinsic aging is the natural aging of the human

body, whereas extrinsic aging is mainly induced by physical

and chemical factors. UV is currently considered to be the

main extrinsic factor leading to skin aging, with it accounting

for ∼80% of facial skin photoaging.

Long-term overexposure

to UV radiation can destroy the structure of the extracellular

matrix of skin tissues, leading to skin fragility, laxity, rough-

ness, dryness, hyper-pigmentation, wrinkle formation,

redness, and an increase in the risk of skin cancer.

3,4

According to the World Health Organization (WHO), it is

expected that the proportion of the world’s population aged 60

years or over will nearly double from 12 to 22%between 2015

and 2050.

People of all ages are generally believed to be inter-

ested in preventing skin aging, thus resulting in a strong

market for anti-photoaging products.

Compounds capable of

inhibiting reactive oxygen species (ROS) were able to protect

the skin tissue against UV-induced photoaging. However, skin

photoaging is a complex process that includes decreased col-

lagen synthesis, increased collagen degradation, accumulation

of ROS in the organism, inhibition of antioxidant enzyme

activity, and release of inflammatory factors.

Therefore, the

eﬀect of a single substance is often limited and cannot com-

prehensively improve skin photoaging, and it is necessary to

investigate the combined eﬀect of diﬀerent chemicals, such as

bioactive peptides and natural antioxidants.

Bioactive peptides, which have most often been derived

from food processing by-products, have been used to produce

commercially valuable food ingredients that have the potential

to trigger certain desirable physiological responses in humans.

Among them, collagen peptides have attracted the attention of

the cosmetic and health care industries in recent years due to

their physiological activities, such as moisture retention

activity, hygroscopicity, tyrosinase inhibitory activity, and anti-

oxidant activity.

Collagen peptides obtained by enzymatic

hydrolysis have been shown to promote endogenous collagen

synthesis and inhibit collagen degradation by stimulating the

TGF-β/Smad signaling pathway.

Previous studies have shown

†Electronic supplementary information (ESI) available. See DOI: https://doi.org/

10.1039/d3fo01516e

State Key Laboratory of Food Science and Resources Jiangnan University, Wuxi,

Jiangsu Province 214122, China. E-mail: liudasong68@163.com;

Fax: +86 510 85326012; Tel: +86 510 85326012

Standard Foods (China) Co. Ltd, Suzhou, Jiangsu Province 215434, China

Le Bonta Wellness Co. Ltd, Shanghai 200131, China

Department of Food Science, Cornell University, Ithaca, NY 14853-7201, USA

Published on 30 May 2023. Downloaded on 6/25/2024 8:46:16 AM.

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